| TM | QB | RTG | TD | INT | SKD | POS | GP | CMP | ATT | CMP% | YDS | AVG | YDS/G | LNG | TD | INT | SACK | SYL | QBR | RTG | ||
| ARI | ARI | BRISSETT | 97.4 | 67.6 | 1.4 | 0.4 | 2.9 | QB | 9 | 204 | 302 | 67.6 | 2188 | 7.2 | 243.1 | 50 | 13 | 4 | 26 | 197 | 42.9 | 97.4 |
| ATL | ATL | COUSINS | 87.1 | 63.9 | 0.6 | 0.2 | 1.2 | QB | 5 | 69 | 108 | 63.9 | 683 | 6.3 | 136.6 | 49 | 3 | 1 | 6 | 35 | 34.7 | 87.1 |
| BAL | BAL | JACKSON (L) | 104.5 | 64.8 | 1.7 | 0.4 | 3.0 | QB | 9 | 147 | 227 | 64.8 | 1841 | 8.1 | 204.6 | 45 | 15 | 4 | 27 | 185 | 57.9 | 104.5 |
| BUF | BUF | ALLEN | 99.8 | 69.4 | 1.6 | 0.8 | 2.3 | QB | 12 | 243 | 350 | 69.4 | 2832 | 8.1 | 236 | 54 | 19 | 10 | 28 | 182 | 59.1 | 99.8 |
| CAR | CAR | YOUNG | 87.9 | 63.4 | 1.5 | 0.8 | 1.8 | QB | 12 | 230 | 363 | 63.4 | 2337 | 6.4 | 194.8 | 54 | 18 | 9 | 22 | 162 | 45.6 | 87.9 |
| CHI | CHI | WILLIAMS | 88.2 | 58.1 | 1.4 | 0.4 | 1.6 | QB | 12 | 230 | 396 | 58.1 | 2,722 | 6.9 | 226.8 | 65 | 17 | 5 | 19 | 126 | 54.8 | 88.2 |
| CIN | CIN | BURROW | 86.9 | 54.9 | 1.3 | 0.0 | 2.0 | QB | 3 | 45 | 82 | 54.9 | 450 | 5.5 | 150 | 43 | 4 | 0 | 6 | 33 | 60 | 86.9 |
| CLE | CLE | SANDERS | 13.5 | 25 | 0.0 | 1.0 | 2.0 | QB | 3 | 31 | 61 | 50.8 | 405 | 6.6 | 135 | 66 | 2 | 2 | 6 | 64 | 7 | 69.4 |
| DAL | DAL | PRESCOTT | 102.4 | 69.3 | 2.1 | 0.7 | 1.4 | QB | 12 | 303 | 437 | 69.3 | 3261 | 7.5 | 271.8 | 74 | 25 | 8 | 17 | 105 | 75.3 | 102.4 |
| DEN | DEN | NIX | 85.8 | 61.6 | 1.6 | 0.8 | 1.1 | QB | 12 | 266 | 432 | 61.6 | 2742 | 6.3 | 228.5 | 52 | 19 | 9 | 13 | 79 | 54 | 85.8 |
| DET | DET | GOFF | 110.2 | 69.8 | 2.1 | 0.4 | 2.2 | QB | 12 | 264 | 378 | 69.8 | 3025 | 8 | 252.1 | 64 | 25 | 5 | 26 | 170 | 57.7 | 110.2 |
| GB | GB | LOVE | 104.3 | 67 | 1.6 | 0.3 | 1.4 | QB | 12 | 242 | 361 | 67 | 2794 | 7.7 | 232.8 | 59 | 19 | 3 | 17 | 126 | 72.9 | 104.3 |
| HOU | HOU | STROUD | 91.1 | 66.1 | 1.2 | 0.7 | 2.1 | QB | 9 | 183 | 277 | 66.1 | 1978 | 7.1 | 219.8 | 50 | 11 | 6 | 19 | 168 | 66.1 | 91.1 |
| IND | IND | JONES | 101.3 | 67.9 | 1.6 | 0.6 | 1.8 | QB | 12 | 256 | 377 | 67.9 | 3041 | 8.1 | 253.4 | 75 | 19 | 7 | 22 | 158 | 64.9 | 101.3 |
| JAC | JAX | LAWRENCE | 81.6 | 59.7 | 1.3 | 0.9 | 2.7 | QB | 12 | 236 | 395 | 59.7 | 2636 | 6.7 | 219.7 | 50 | 16 | 11 | 32 | 203 | 44.5 | 81.6 |
| KC | KC | MAHOMES | 96.5 | 64.6 | 1.8 | 0.6 | 2.3 | QB | 12 | 285 | 441 | 64.6 | 3238 | 7.3 | 269.8 | 61 | 22 | 7 | 27 | 160 | 73.1 | 96.5 |
| LAC | LAC | HERBERT (Q) | 94.9 | 66.9 | 1.8 | 0.8 | 3.2 | QB | 12 | 265 | 396 | 66.9 | 2842 | 7.2 | 236.8 | 60 | 21 | 10 | 38 | 224 | 60.5 | 94.9 |
| LAR | LAR | STAFFORD | 111.7 | 66.3 | 2.7 | 0.3 | 1.4 | QB | 12 | 266 | 401 | 66.3 | 3073 | 7.7 | 256.1 | 88 | 32 | 4 | 17 | 114 | 67 | 111.7 |
| LVR | LV | OCCONELL | 84 | 67.3 | 1.3 | 1.2 | 3.8 | QB | 12 | 253 | 376 | 67.3 | 2532 | 6.7 | 211 | 61 | 15 | 14 | 46 | 331 | 30.8 | 84 |
| MIA | MIA | TAGOVAILOA | 85.9 | 67.2 | 1.4 | 1.2 | 2.1 | QB | 12 | 225 | 335 | 67.2 | 2280 | 6.8 | 190 | 47 | 17 | 14 | 25 | 156 | 40 | 85.9 |
| MIN | MIN | * JMAC | 57.9 | 54.1 | 1.0 | 1.7 | 3.3 | QB | 6 | 86 | 159 | 54.1 | 929 | 5.8 | 154.8 | 62 | 6 | 10 | 20 | 112 | 24.1 | 57.9 |
| NE | NE | MAYE | 111.9 | 71.5 | 1.8 | 0.5 | 3.1 | QB | 13 | 276 | 386 | 71.5 | 3412 | 8.8 | 262.5 | 72 | 23 | 6 | 40 | 178 | 72.8 | 111.9 |
| NOS | NO | SHOUGH | 83.6 | 65.2 | 0.8 | 0.7 | 2.3 | QB | 6 | 107 | 164 | 65.2 | 1068 | 6.5 | 178 | 62 | 5 | 4 | 14 | 98 | 36.5 | 83.6 |
| NYG | NYG | DART | 94.1 | 63.6 | 1.1 | 0.3 | 2.3 | QB | 10 | 145 | 228 | 63.6 | 1556 | 6.8 | 155.6 | 44 | 11 | 3 | 23 | 94 | 64.7 | 94.1 |
| NYJ | NYJ | TAYLOR | 77.5 | 60.8 | 1.0 | 0.8 | 2.8 | QB | 5 | 79 | 130 | 60.8 | 773 | 5.9 | 154.6 | 52 | 5 | 4 | 14 | 82 | 57.5 | 77.5 |
| PHI | PHI | HURTS | 103.9 | 66.1 | 1.6 | 0.2 | 2.3 | QB | 12 | 226 | 342 | 66.1 | 2514 | 7.4 | 209.5 | 79 | 19 | 2 | 27 | 159 | 54.5 | 103.9 |
| PIT | PIT | RODGERS | 95.4 | 65.2 | 1.7 | 0.6 | 1.8 | QB | 11 | 202 | 310 | 65.2 | 2086 | 6.7 | 189.6 | 80 | 19 | 7 | 20 | 130 | 40.5 | 95.4 |
| SAN | SAN | PURDY | 87.7 | 66.3 | 1.8 | 1.4 | 0.8 | QB | 5 | 106 | 160 | 66.3 | 1147 | 7.2 | 229.4 | 45 | 9 | 7 | 4 | 36 | 68.5 | 87.7 |
| SEA | SEA | DARNOLD | 103.1 | 68.2 | 1.6 | 0.8 | 1.3 | QB | 12 | 221 | 324 | 68.2 | 2913 | 9 | 242.8 | 67 | 19 | 10 | 15 | 101 | 64.3 | 103.1 |
| TB | TB | MAYFIELD (L) | 93.4 | 62.8 | 1.6 | 0.4 | 2.0 | QB | 12 | 243 | 387 | 62.8 | 2600 | 6.7 | 216.7 | 77 | 19 | 5 | 24 | 165 | 61.2 | 93.4 |
| TEN | TEN | WARD | 75.2 | 59.7 | 0.6 | 0.5 | 4.0 | QB | 12 | 246 | 412 | 59.7 | 2351 | 5.7 | 195.9 | 47 | 7 | 6 | 48 | 362 | 31.8 | 75.2 |
| WAS | WSH | DANIELS | 94.4 | 62.5 | 1.3 | 0.3 | 2.8 | 94.4 | 6 | 105 | 168 | 62.5 | 1184 | 7 | 197.3 | 50 | 8 | 2 | 17 | 78 | 51.2 | 94.4 |